Nutritionally variant streptococci
From IDWiki
Background
- Require pyridoxine (vitamin B6) supplementation to group
- Also called pyridoxal-dependent or stalliting streptococci
Organisms
Clinical Manifestations
- Subacute bacterial endocarditis is the most well-known disease association
Management
- Susceptibilities shown below are from one small study1
| Antibiotic | Abiotrophia defectiva | Granulicatella adiacens | Granulicatella elegans |
|---|---|---|---|
| Penicillin | 57% | 82% | 100% |
| Ampicillin | 86% | 100% | 100% |
| Piperacillin | 0% | 53% | 100% |
| Cefazolin | 29% | 88% | 100% |
| Ceftriaxone | 100% | 76% | 100% |
| Ceftazidime | 0% | 0% | 50% |
| Imipenem | 100% | 100% | 100% |
| Gentamicin | 0% | 0% | 0% |
| Ciprofloxacin | 100% | 18% | 17% |
| Minocycline | 57% | 94% | 100% |
| Vancomycin | 100% | 100% | 83% |
| TMP-SMX | 14% | 0% | 17% |
References
- ^ Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima. Antimicrobial Susceptibilities of Oral Isolates of Abiotrophia and Granulicatella According to the Consensus Guidelines for Fastidious Bacteria. Medicines. 2018;5(4):129. doi:10.3390/medicines5040129.
- ^ Kunatum Prasidthrathsint, Mark A. Fisher. Robin Patel. Antimicrobial Susceptibility Patterns among a Large, Nationwide Cohort of Abiotrophia and Granulicatella Clinical Isolates. Journal of Clinical Microbiology. 2017;55(4):1025-1031. doi:10.1128/jcm.02054-16.
- ^ Ammara Mushtaq, Kerryl E. Greenwood-Quaintance, Nicolynn C. Cole, Peggy C. Kohner, Sherry M. Ihde, Gregory J. Strand, Lance W. Harper, Abinash Virk, Robin Patel. Differential Antimicrobial Susceptibilities of Granulicatella adiacens and Abiotrophia defectiva. Antimicrobial Agents and Chemotherapy. 2016;60(8):5036-5039. doi:10.1128/aac.00485-16.
