Leukemoid reaction
From IDWiki
Background
- Significant leukocytosis and neutrophilia in the absence of a hematologic malignancy
- e.g. WBC ≥30-50 with ≥50% granulocytes
Differential Diagnosis
- Infections
- Sepsis, pneumonia, urinary tract infection
- Clostridioides difficile colitis (often quite high)
- Disseminated tuberculosis
- Severe shigellosis
- Postpartum Clostridium sordellii
- Inflammation
- Pancreatitis
- Mesenteric inflammatory pseudotumor
- Malignancies
- Carcinomas (lung, oropharyngeal, gastrointestinal, genitourinary)
- Hodgkin lymphoma
- Melanoma
- Sarcoma
- Drugs
- Corticosteroids
- Minocycline
- Recombinant hematopoietic growth factors
- Miscellaneous
- Splenectomy
- Ethylene glycol intoxication
- Severe hemorrhage or acute hemolysis
- Alcoholic steatohepatitis
Further Reading
- Leukemoid reaction: Spectrum and prognosis of 173 adult patients. Clin Infect Dis. 2013;57:e177. doi: 10.1093/cid/cit562
- An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Internal Med. 2006 Oct;17(6):394-8. doi: 10.1016/j.ejim.2006.04.004
References
- ^ Vissaria Sakka, Sotirios Tsiodras, Evangelos J. Giamarellos-Bourboulis, Helen Giamarellou. An update on the etiology and diagnostic evaluation of a leukemoid reaction. European Journal of Internal Medicine. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.
