Post-transplant acute limbic encephalitis

• Limbic encephalitis syndrome following hematopoietic stem cell transplantation

Background

• Caused by HHV-6B

Clinical Presentation

• Onset 2 weeks to 2 months after transplant
• Presents with confusion, amnesia, hallucinations
• Can cause seizures
• Hyponatremia is common

Management

• Treat seizures with antiepileptic medications
• Treat any possible concomitant risk factors such as hyponytremia
• Antivirals: acyclovir, ganciclovir, or foscarnet for 10 days to 4 weeks