Antibiotics in sodium restriction

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  • The delivery of intravenous antibiotics may be associated with a significant sodium load, which can exacerbate preexisting comorbidities such as heart failure
Antibiotic Total daily sodium (g)
β-lactams
Penicillin G potassium 2.34
Penicillin G sodium 3.1
Ampicillin 2.91
Ampicillin-sulbactam 1.88 to 2.34
Oxacillin 3.32
Nafcillin 3.55
Piperacillin-tazobactam 2.28 to 2.56
Cefazolin 1.2 to 1.35
Ceftriaxone 0.47 to 1.18
Ceftazidime 1.22 to 1.39
Cefipime 1.17
Ceftaroline 1.27
Aztreonam 1.06
Ertapenem 1.33 to 1.6
Imipenem 1.71
Fluoroquinolones
Ciprofloxacin 0
Levofloxacin 0.28
Other
Azithromycin 1
Clindamycin 1.06 to 1.42
Vancomycin 3.54
Daptomycin 0.39
Linezolid 2.39
Doxycycline 0.78

Further Reading

  • Sodium content of intravenous antibiotic preparations. Open Forum Infect Dis. 2019. doi: 10.1093/ofid/ofz508