West Nile virus

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Revision as of 23:39, 14 August 2019 by Aidan (talk | contribs) (Aidan moved page RNA West Nile virus (WNV) to West Nile virus without leaving a redirect)

West Nile virus (WNV)

Diagnosis

  • Serology
    • Serum or CSF for IgM antibodies is the standard test; usually positive by 3 to 8 days, and persist for 2 to 3 months
      • If submitted CSF, must also submit serum
    • May cross-react with other flaviviruses
    • Can be seronegative if immunosuppressed (e.g. rituximab), therefore may need to do PCR
  • PCR
    • RNA virus, therefore needs reverse transcriptase step (RT-PCR)
    • Can be done on serum, CSF, and tissue
  • On MRI, may have a slight preference for thalamus