Classification
- Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida
Indications
- Fungal infections
Monitoring
- ECG for QT prolongation
- Liver enzymes for hepatitis
Pharmacokinetics
- Good oral bioavailability
- CNS penetration
Adverse Drug Reactions
- Best side effect profiles of the antifungals
- Before starting, check:
- Liver enzymes as baseline (hepatitis
- Creatinine (requires renal dosing)
- EKG (QTc prolongation)
- Beware drug-drug interactions, especially with new DOACs
