Criteria

Major criteria

Blood culture positive for IE
- Typical bacteria from 2 separate blood cultures
  - Viridans-group streptococci, Streptococcus bovis, HACEK group, Staphylococcus aureus
  - Community-acquired enterococci in the absence of another focus
- Consistent organisms with persistently-positive blood cultures
  - ≥2 positive cultures drawn >12 h apart
  - 3 or a majority of ≥4 cultures positive, with first and last sample drawn at least 1 h apart
- Single positive blood culture for Coxiella burnetii or antiphase I IgG antibody titre >1:800
Evidence of endocardial involvement
- Echocardiogram positive for IE
- New valvular regurgitation

Predisposing heart condition or injection drug use
Fever >38ºC
Vascular phenomena
- Major arterial emboli
- Septic pulmonary infarcts
- Mycotic aneurysm
- Intracranial hemorrhage
- Conjunctival hemorrhages
- Janeway lesions
Immunologic phenomena
- Glomerulonephritis
- Osler nodes
- Roth spots
- Rheumatoid factor
Positive blood cultures not meeting a major criterion, or consistent serology that is not Coxiella

Definite infective endocarditis if meets pathologic criteria, or if one of:
- 2 major, or
- 1 major and 3 minor, or
- 5 minor
Possible infective endocarditis if one of
- 1 major and 1 minor, or
- 3 minor