Burkholderia cepacia complex: Difference between revisions
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Burkholderia cepacia complex
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** [[Burkholderia multivorans]] (genomovar II) |
** [[Burkholderia multivorans]] (genomovar II) |
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** [[Burkholderia dolosa]] (genomovar VI) |
** [[Burkholderia dolosa]] (genomovar VI) |
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* Environmental organism |
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* Multiple mechanisms of resistance: |
* Multiple mechanisms of resistance: |
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** β-lactamases |
** β-lactamases |
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* Opportunistic lung infections, primarily of [[cystic fibrosis]] and [[lung transplant]] patients |
* Opportunistic lung infections, primarily of [[cystic fibrosis]] and [[lung transplant]] patients |
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* Colonizes the lungs of patients with [[cystic fibrosis]] and portends a poor prognosis |
* Colonizes the lungs of patients with [[cystic fibrosis]] and portends a poor prognosis |
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* Occasionally causes nosocomial outbreaks traced back to aqueous pharmaceutical products |
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== Management == |
== Management == |
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Revision as of 16:44, 6 February 2023
Background
- Gram-negative bacillus
- Classified into nine genomovars (phenotypically similar but genotypically distinct)
- Burkholderia cenocepacia (genomovar III)
- Burkholderia multivorans (genomovar II)
- Burkholderia dolosa (genomovar VI)
- Environmental organism
- Multiple mechanisms of resistance:
- β-lactamases
- RND efflux pumps
- Altered LPS conferring polymixin resistance
- Gyrase mutations conferring fluoroquinolone resistance
Clinical Manifestations
- Opportunistic lung infections, primarily of cystic fibrosis and lung transplant patients
- Colonizes the lungs of patients with cystic fibrosis and portends a poor prognosis
- Occasionally causes nosocomial outbreaks traced back to aqueous pharmaceutical products
Management
- Should be guided by antimicrobial susceptibility testing
- Antibiotic options include:
- TMP-SMX (preferred, if susceptible)
- Ceftazidime and ceftazidime-avibactam
- Meropenem and imipenem
- Minocycline
