Lamivudine: Difference between revisions

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== Dosing ==


* [[HIV]] treatment: 150 mg p.o. twice daily or 300 mg p.o. once daily
== Pediatric Dosing ==
* [[Hepatitis B]]: 100 mg p.o. once daily
=== Neonatal HIV prophylaxis ===

=== Renal Dosing ===

* GFR >=50: usual dosing
* GFR 30-49: 150 mg p.o. once daily.
* GFR 15-29: 150 mg p.o. on day 1 followed by 100 mg p.o. once daily
* GFR 5-14: 150 mg p.o. on daily 1 followed by 50 mg p.o. once daily
* GFR <5: 50 mg p.o. on day 1 followed by 25 mg p.o. once daily
* Hemodialysis: 50 mg p.o. once followd by 25 mg p.o. once daily post dialysis
* Peritoneal dialysis: 50 mg p.o. once followed by 25 mg p.o. once daily

=== Pediatric Dosing ===

==== Neonatal HIV prophylaxis ====
* ≥32 weeks gestation at birth: 2 mg/kg PO q12h until age 4 weeks, then 4 mg/kg (max 150 mg) PO q12h
* ≥32 weeks gestation at birth: 2 mg/kg PO q12h until age 4 weeks, then 4 mg/kg (max 150 mg) PO q12h



Latest revision as of 17:15, 16 January 2023

Dosing

  • HIV treatment: 150 mg p.o. twice daily or 300 mg p.o. once daily
  • Hepatitis B: 100 mg p.o. once daily

Renal Dosing

  • GFR >=50: usual dosing
  • GFR 30-49: 150 mg p.o. once daily.
  • GFR 15-29: 150 mg p.o. on day 1 followed by 100 mg p.o. once daily
  • GFR 5-14: 150 mg p.o. on daily 1 followed by 50 mg p.o. once daily
  • GFR <5: 50 mg p.o. on day 1 followed by 25 mg p.o. once daily
  • Hemodialysis: 50 mg p.o. once followd by 25 mg p.o. once daily post dialysis
  • Peritoneal dialysis: 50 mg p.o. once followed by 25 mg p.o. once daily

Pediatric Dosing

Neonatal HIV prophylaxis

  • ≥32 weeks gestation at birth: 2 mg/kg PO q12h until age 4 weeks, then 4 mg/kg (max 150 mg) PO q12h