Antimicrobial stewardship program: Difference between revisions

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== Core Elements ==
== Core Elements ==


=== Hospital Leadership Commitment ===
* Senior hospital management leadership towards antimicrobial stewardship
* Need support from senior leadership, including chief medical officer, chief nursing officer, and director of pharmacy
* Need leaders to give time to manage the program, resource (including staffing)
* Accountability and responsibilities
* Accountability and responsibilities
* Available expertise on infection management
* Available expertise on infection management

Revision as of 17:03, 10 August 2022

Background

  • Program to ensure that antimicrobials are used appropriately, in order to improve patient outcomes

Core Elements

Hospital Leadership Commitment

  • Need support from senior leadership, including chief medical officer, chief nursing officer, and director of pharmacy
  • Need leaders to give time to manage the program, resource (including staffing)
  • Accountability and responsibilities
  • Available expertise on infection management
  • Education and practical training
  • Other actions aiming at responsible antimicrobial use
  • Monitoring and surveillance
  • Reporting and feedback

Possible Interventions

  • Preauthorization
  • Prospective audit and feedback
  • Didactic educational activities, including lectures and pamphlets
  • Facility-specific clinical practice guidelines for common syndromes
  • Reducing use of antibiotics with increased risk of C. difficile infection
  • Prescriber-led review, including antibiotics time-outs and stop orders
  • Computerized clinical decision-making support at the time of prescribing
  • PK monitoring and adjustment of aminoglycosides and vancomycin
  • Alternative dosing of β-lactams
  • Interventions to increase the use of oral antibiotics for initial therapy as well as timely transition from IV to oral antibiotics
  • Interventions to reduce the duration of antibiotics to shortest effective duration
  • Allergy assessments and penicillin skin testing for patients with reported β-lactam allergy
  • Development of stratified antibiograms (e.g. by location or age)
  • Selective and cascade reporting of antimicrobial susceptibility
  • Rapid viral testing for respiratory pathogens to reduce the use of inappropriate antibiotics
  • Rapid diagnostic testing on blood specimens
  • Serial procalcitonin in ICU patients

Recommended Against

  • Cycling antibiotics

Further Reading

  • How to start an antimicrobial stewardship programme in a hospital. Clin Microbiol Infect. 2019;26(4):447-453. doi: 10.1016/j.cmi.2019.08.007
  • Implementing an Antibiotic Stewardship Program: Guidelines by the IDSA and the SHEA. Clin Infect Dis. 2016;62(10):e51-e77. doi: 10.1093/cid/ciw118
  • IDSA and the SHEA Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship. Clin Infect Dis. 2007;44:159-77. doi: 10.1086/510393