Artesunate: Difference between revisions

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== Background ==
* Artemesinin compound indicated for the treatment of severe [[malaria]]
* Artemesinin compound indicated for the treatment of severe [[malaria]]

* Dosing:
== Dosing ==
** Adults and children ≥20 kg: 2.4 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours
** Children <20 kg: 3.0 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours
* Adults and children ≥20 kg: 2.4 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours, followed by oral therapy
* Children <20 kg: 3.0 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours, followed by oral therapy

== Safety ==

=== Post-Artesunate Delayed Hemolysis ===

* Likely the result from delayed clearance of previously-infected erythrocytes rather than toxic effect of the drug
* Recommend weekly CBC for at least 4 weeks following treatment, as well as clinical monitoring for signs and symptoms of anemia and jaundice


[[Category:Antimalarials]]
[[Category:Antimalarials]]

Latest revision as of 13:53, 22 June 2021

Background

  • Artemesinin compound indicated for the treatment of severe malaria

Dosing

  • Adults and children ≥20 kg: 2.4 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours, followed by oral therapy
  • Children <20 kg: 3.0 mg/kg at 0 hour, 12 hours, 24 hours, and 48 hours, followed by oral therapy

Safety

Post-Artesunate Delayed Hemolysis

  • Likely the result from delayed clearance of previously-infected erythrocytes rather than toxic effect of the drug
  • Recommend weekly CBC for at least 4 weeks following treatment, as well as clinical monitoring for signs and symptoms of anemia and jaundice