Cefiderocol: Difference between revisions

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== Background ==
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==Background==
   
=== Mechanism of Activity ===
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===Mechanism of Activity===
   
* Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin
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*Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin
   
=== Spectrum of Activity ===
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===Spectrum of Activity===
   
* Active against all Ambler class beta-lactamases, including carbapenemases
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*Active against all Ambler class beta-lactamases, including carbapenemases
* Active against [[Acinetobacter]], [[Enterobacterales]], [[Pseudomonas]], [[Burkholderia]], and [[Stenotrophomonas]]
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*Active against [[Acinetobacter]], [[Enterobacterales]], [[Pseudomonas]], [[Burkholderia]], and [[Stenotrophomonas]]
* Not active against Gram-positive bacteria
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*Not active against Gram-positive bacteria
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== Dosing ==
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* Cefiderocol 2 g IV q8h, infused over 3 hours
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[[Category:Siderophore cephalosporins]]

Revision as of 09:34, 12 September 2020

Background

Mechanism of Activity

  • Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin

Spectrum of Activity

Dosing

  • Cefiderocol 2 g IV q8h, infused over 3 hours