Marburg virus: Difference between revisions

Revision as of 13:39, 28 August 2020

Background

Microbiology

Negative-sense single-stranded RNA virus in the Filoviridae family
Genus contains two species
- Marburg virus
- Ravn virus

Epidemiology

Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases
Animal reservoir is fruit bat, with a sylvian cycle that occasionally spills over into human populations
- The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa

Clinical Manifestations

Incubation period 2 to 21 days
Starts with high fever, severe headache malaise
Followed by multi-system involvement as early as day 3
- Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week)
- Chest pain, dyspnea, cough
- Hypotension, edema, maculopapular rash
- Headache, confusion
Mortality 23 to 90%

Diagnosis

RT-PCR at the National Microbiology Laboratory
- Inform microbiology lab beforehand and contact Public Health for collection instructions

Management

Good supportive care decreases mortality substantially
Experimental therapies include favipiravir and monoclonal antibodies

Prevent

Vaccination is under investigation

@@ Line 1: / Line 1: @@
 ==Background==
-=== Microbiology ===
+===Microbiology===
 *Negative-sense single-stranded RNA virus in the [[Filoviridae]] family
@@ Line 8: / Line 8: @@
 **Ravn virus
-=== Epidemiology ===
+===Epidemiology===
-* Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases
+*Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases
-* Animal reservoir is [[Reservoir::fruit bat]], with a sylvian cycle that occasionally spills over into human populations
+*Animal reservoir is [[Reservoir::fruit bat]], with a sylvian cycle that occasionally spills over into human populations
-** The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa
+**The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa
-== Clinical Manifestations ==
+==Clinical Manifestations==
-* Incubation period [[Usual incubation period::2 to 21 days]]
+*Incubation period [[Usual incubation period::2 to 21 days]]
-* Starts with high fever, severe headache malaise
+*Starts with high fever, severe headache malaise
-* Followed by multi-system involvement as early as day 3
+*Followed by multi-system involvement as early as day 3
-** Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week)
+**Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week)
-** Chest pain, dyspnea, cough
+**Chest pain, dyspnea, cough
-** Hypotension, edema, maculopapular rash
+**Hypotension, edema, maculopapular rash
-** Headache, confusion
+**Headache, confusion
-* Mortality 23 to 90%
+*Mortality 23 to 90%
-== Management ==
+== Diagnosis ==
+* RT-PCR at the National Microbiology Laboratory
-* Good supportive care decreases mortality substantially
+** Inform microbiology lab beforehand and contact Public Health for collection instructions
-* Experimental therapies include [[favipiravir]] and monoclonal antibodies
-== Prevent ==
+==Management==
+*Good supportive care decreases mortality substantially
-* Vaccination is under investigation
+*Experimental therapies include [[favipiravir]] and monoclonal antibodies
+==Prevent==
+*Vaccination is under investigation
 [[Category:Filoviridae]]