Tissue penetration of antimicrobials: Difference between revisions
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Revision as of 13:48, 24 August 2020
| Class | Antimicrobial | Blood | CNS | Urine | Necrotic |
|---|---|---|---|---|---|
| Antibiotics | |||||
| Penicillins | β-lactamase inhibitors | NO | |||
| ampicillin | YES | NO | |||
| Cephalosporins | first-generation cephalosporins | NO | NO | ||
| second-generation cephalosporins | NO | ||||
| cefepime | YES | ||||
| ceftazidime | YES | YES | |||
| Cephamycins | cephamycins | NO | |||
| cefoxitin | NO | ||||
| Carbapenems | imipenem | YES | |||
| Aminoglycosides | NO | ||||
| Fluoroquinolones | NO? | YES | |||
| Lincosamides | clindamycin | NO | YES | ||
| Macrolides | NO | ||||
| Nitroimidazoles | metronidazole | YES | |||
| Tetracyclines | tetracyclines | NO | |||
| doxycycline | YES | ||||
| Chloramphenicol | chloramphenicol | YES | |||
| Antifungals | |||||
| Azoles | fluconazole | YES | |||
References
- ^ Roland Nau, Fritz Sörgel, Helmut Eiffert. Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections. Clinical Microbiology Reviews. 2010;23(4):858-883. doi:10.1128/cmr.00007-10.
- ^ Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.
- a b c d e f g h i j k l m n o p q r L. Brockhaus, D. Goldblum, L. Eggenschwiler, S. Zimmerli, C. Marzolini. Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics. Clinical Microbiology and Infection. 2019;25(11):1364-1369. doi:10.1016/j.cmi.2019.01.017.
- a b Takashi Suzuki, Toshihiko Uno, Guangming Chen, Yuichi Ohashi. Ocular distribution of intravenously administered micafungin in rabbits. Journal of Infection and Chemotherapy. 2008;14(3):204-207. doi:10.1007/s10156-008-0612-5.
- a b c d e f g h Timothy Felton, Peter F. Troke, William W. Hope. Tissue Penetration of Antifungal Agents. Clinical Microbiology Reviews. 2014;27(1):68-88. doi:10.1128/cmr.00046-13.
- ^ Tony H. Huynh, Mark W. Johnson, Grant M. Comer, Douglas N. Fish. Vitreous Penetration of Orally Administered Valacyclovir. American Journal of Ophthalmology. 2008;145(4):682-686. doi:10.1016/j.ajo.2007.11.016.
- ^ Luis F. López-Cortés, R. Ruiz-Valderas, M. J. Lucero-Muñoz, E. Cordero, M. T. Pastor-Ramos, J. Marquez. Intravitreal, Retinal, and Central Nervous System Foscarnet Concentrations after Rapid Intravenous Administration to Rabbits. Antimicrobial Agents and Chemotherapy. 2000;44(3):756-759. doi:10.1128/aac.44.3.756-759.2000.
