Tissue penetration of antimicrobials: Difference between revisions
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!Necrotic |
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! colspan="6" |Antibiotics |
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|β-lactamase inhibitors |
|β-lactamase inhibitors |
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|NO |
|NO |
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|[[ampicillin]] |
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|YES |
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|NO |
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|NO |
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|NO |
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|[[cefepime]] |
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|YES |
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|[[ceftazidime]] |
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|YES |
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|YES |
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|[[cephamycins]] |
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|NO |
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|[[cefoxitin]] |
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|NO |
|NO |
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|[[imipenem]] |
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|YES |
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|Aminoglycosides |
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|NO |
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|Fluoroquinolones |
|Fluoroquinolones |
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|NO? |
|NO? |
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|YES |
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|Macrolides |
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|NO |
|NO |
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|Nitroimidazoles |
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|[[metronidazole]] |
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|YES |
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|[[tetracyclines]] |
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|NO |
|NO |
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|[[doxycycline]] |
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|YES |
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|Chloramphenicol |
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|[[chloramphenicol]] |
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|YES |
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! colspan="6" |Antifungals |
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|Azoles |
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|[[fluconazole]] |
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|YES |
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[[Category:Antimicrobials]] |
[[Category:Antimicrobials]] |
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Revision as of 13:47, 24 August 2020
| Class | Antimicrobial | Blood | CNS | Urine | Necrotic |
|---|---|---|---|---|---|
| Antibiotics | |||||
| Penicillins | β-lactamase inhibitors | NO | |||
| ampicillin | YES | NO | |||
| Cephalosporins | first- and second-generation cephalosporins | NO | NO | ||
| cefepime | YES | ||||
| ceftazidime | YES | YES | |||
| Cephamycins | cephamycins | NO | |||
| cefoxitin | NO | ||||
| Carbapenems | imipenem | YES | |||
| Aminoglycosides | NO | ||||
| Fluoroquinolones | NO? | YES | |||
| Lincosamides | clindamycin | NO | YES | ||
| Macrolides | NO | ||||
| Nitroimidazoles | metronidazole | YES | |||
| Tetracyclines | tetracyclines | NO | |||
| doxycycline | YES | ||||
| Chloramphenicol | chloramphenicol | YES | |||
| Antifungals | |||||
| Azoles | fluconazole | YES | |||
References
- ^ Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.
