Human papillomavirus: Difference between revisions
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− | == |
+ | ==Background== |
+ | |||
− | * Oncogenic double-stranded DNA virus in the ''Papillomaviridae'' family |
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+ | *Oncogenic double-stranded DNA virus in the ''Papillomaviridae'' family |
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+ | |||
+ | == Clinical Manifestations == |
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+ | |||
+ | * Most commonly associated with warts (including genital warts), cervical cancer, and penile cancer |
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+ | |||
+ | {| class="wikitable" |
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+ | !Disease |
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+ | !Common Genotypes |
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+ | !Uncommon Genotypes |
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+ | |- |
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+ | |[[Plantar wart|Plantar warts]] |
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+ | |1, 2, 27 |
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+ | | rowspan="2" |4, 26, 28, 29, 41, 57, 63, 65, 77, 117, 125, 128, 129, 130, 131, 132, 133, 148, 149, 179, 184 |
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+ | |- |
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+ | |[[Wart|Common warts]] |
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+ | |1, 2, 4, 27 |
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+ | |- |
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+ | |[[Wart|Warts]] of meat, poultry, and fish handlers |
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+ | |2, 7 |
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+ | |1, 3, 4, 10, 28 |
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+ | |- |
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+ | |[[Wart|Flat and intermediate warts]] |
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+ | |3, 10 |
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+ | |27, 28, 38, 41, 49, 75, 76, 126 |
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+ | |- |
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+ | |[[Epidermodysplasia verruciformis]] |
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+ | |5, 8, 9, 12, 14, 15, 17 |
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+ | |19, 20, 21, 22, 23, 24, 25, 36, 37, 38, 47, 49, 50, 75, 93 |
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+ | |- |
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+ | |[[Condylomata acuminata]] |
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+ | |6, 11 |
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+ | |16, 18, 26, 31, 33, 35, 40, 42, 43, 44, 45, 51, 52, 53, 54, 55, 56, 58, 59, 66, 68, 70, 153, 175, 178, 180, 200, 201, 202 |
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+ | |- |
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+ | |[[Intraepithelial neoplasia]] |
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+ | | |
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+ | | |
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+ | |- |
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+ | |Intraepithelial neoplasia (unspecified) |
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+ | | |
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+ | |26, 30, 34, 39, 40, 53, 57, 59, 61, 62, 67, 68, 69, 71, 81, 83 |
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+ | |- |
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+ | |Intraepithelial neoplasia (low-grade) |
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+ | |6, 11 |
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+ | |16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 54, 61, 70, 72, 74 |
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+ | |- |
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+ | |Intraepithelial neoplasia (high-grade) |
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+ | |16, 18 |
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+ | |6, 11, 31, 33, 34, 35, 39, 42, 44, 45, 51, 52, 56, 58, 66, 67 |
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+ | |- |
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+ | |[[Cervical carcinoma]] |
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+ | |16, 18 |
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+ | |26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 67, 68, 73, 82 |
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+ | |- |
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+ | |Recurrent [[respiratory papillomatosis]] |
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+ | |6, 11 |
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+ | |16, 18, 31, 33, 35, 39 |
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+ | |- |
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+ | |Focal epithelial hyperplasia of Heck |
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+ | |13, 32 |
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+ | |18, 33, 45 |
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+ | |- |
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+ | |[[Conjunctival papilloma|Conjunctival papillomas]] and [[Conjunctival carcinoma|carcinomas]] |
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+ | |6, 11, 16 |
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+ | | |
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+ | |} |
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+ | |||
+ | == Prevention == |
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+ | |||
+ | === Vaccination === |
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+ | {| class="wikitable" |
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+ | ! rowspan="3" |Vaccine |
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+ | ! rowspan="3" |Genotypes |
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+ | ! colspan="6" |Schedule |
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+ | |- |
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+ | ! colspan="3" |Girls and Women |
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+ | ! colspan="3" |Boys and Men |
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+ | |- |
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+ | !9 to 15 years |
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+ | !≥15 years |
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+ | !Immunocompromised |
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+ | !9 to 15 years |
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+ | !≥15 years |
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+ | !Immunocompromised |
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+ | |- |
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+ | |Cervarix |
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+ | |16, 18 |
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+ | | rowspan="3" |2 or 3 dose |
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+ | | rowspan="3" |3 dose |
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+ | | rowspan="3" |3 dose |
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+ | | colspan="3" |not indicated |
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+ | |- |
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+ | |Gardasil |
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+ | |6, 11, 16, 18 |
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+ | | rowspan="2" |2 or 3 dose |
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+ | | rowspan="2" |3 dose |
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+ | | rowspan="2" |3 dose |
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+ | |- |
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+ | |Gardasil-9 |
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+ | |6, 11, 16, 18, 31, 33, 45, 51, 58 |
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+ | |} |
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+ | |||
+ | * Two-dose schedule |
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+ | ** Only indicated for children aged at least 9 to less than 15 years |
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+ | ** Given at 0 and 6 months |
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+ | * Three-dose schedule |
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+ | ** Indicated for everyone, including children 9 years and older, men and women 15 years and older and immunocompromised people |
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+ | ** Given at 0, 2, and 6 months |
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[[Category:DNA viruses]] |
[[Category:DNA viruses]] |
Revision as of 10:42, 14 August 2020
Background
- Oncogenic double-stranded DNA virus in the Papillomaviridae family
Clinical Manifestations
- Most commonly associated with warts (including genital warts), cervical cancer, and penile cancer
Disease | Common Genotypes | Uncommon Genotypes |
---|---|---|
Plantar warts | 1, 2, 27 | 4, 26, 28, 29, 41, 57, 63, 65, 77, 117, 125, 128, 129, 130, 131, 132, 133, 148, 149, 179, 184 |
Common warts | 1, 2, 4, 27 | |
Warts of meat, poultry, and fish handlers | 2, 7 | 1, 3, 4, 10, 28 |
Flat and intermediate warts | 3, 10 | 27, 28, 38, 41, 49, 75, 76, 126 |
Epidermodysplasia verruciformis | 5, 8, 9, 12, 14, 15, 17 | 19, 20, 21, 22, 23, 24, 25, 36, 37, 38, 47, 49, 50, 75, 93 |
Condylomata acuminata | 6, 11 | 16, 18, 26, 31, 33, 35, 40, 42, 43, 44, 45, 51, 52, 53, 54, 55, 56, 58, 59, 66, 68, 70, 153, 175, 178, 180, 200, 201, 202 |
Intraepithelial neoplasia | ||
Intraepithelial neoplasia (unspecified) | 26, 30, 34, 39, 40, 53, 57, 59, 61, 62, 67, 68, 69, 71, 81, 83 | |
Intraepithelial neoplasia (low-grade) | 6, 11 | 16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 54, 61, 70, 72, 74 |
Intraepithelial neoplasia (high-grade) | 16, 18 | 6, 11, 31, 33, 34, 35, 39, 42, 44, 45, 51, 52, 56, 58, 66, 67 |
Cervical carcinoma | 16, 18 | 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 67, 68, 73, 82 |
Recurrent respiratory papillomatosis | 6, 11 | 16, 18, 31, 33, 35, 39 |
Focal epithelial hyperplasia of Heck | 13, 32 | 18, 33, 45 |
Conjunctival papillomas and carcinomas | 6, 11, 16 |
Prevention
Vaccination
Vaccine | Genotypes | Schedule | |||||
---|---|---|---|---|---|---|---|
Girls and Women | Boys and Men | ||||||
9 to 15 years | ≥15 years | Immunocompromised | 9 to 15 years | ≥15 years | Immunocompromised | ||
Cervarix | 16, 18 | 2 or 3 dose | 3 dose | 3 dose | not indicated | ||
Gardasil | 6, 11, 16, 18 | 2 or 3 dose | 3 dose | 3 dose | |||
Gardasil-9 | 6, 11, 16, 18, 31, 33, 45, 51, 58 |
- Two-dose schedule
- Only indicated for children aged at least 9 to less than 15 years
- Given at 0 and 6 months
- Three-dose schedule
- Indicated for everyone, including children 9 years and older, men and women 15 years and older and immunocompromised people
- Given at 0, 2, and 6 months