Human papillomavirus: Difference between revisions
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Created page with "== Background == * Oncogenic double-stranded DNA virus in the ''Papillomaviridae'' family Category:DNA viruses Category:Infectious diseases" |
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==Background== |
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* Oncogenic double-stranded DNA virus in the ''Papillomaviridae'' family |
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*Oncogenic double-stranded DNA virus in the ''Papillomaviridae'' family |
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== Clinical Manifestations == |
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* Most commonly associated with warts (including genital warts), cervical cancer, and penile cancer |
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{| class="wikitable" |
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!Disease |
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!Common Genotypes |
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!Uncommon Genotypes |
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|- |
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|[[Plantar wart|Plantar warts]] |
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|1, 2, 27 |
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| rowspan="2" |4, 26, 28, 29, 41, 57, 63, 65, 77, 117, 125, 128, 129, 130, 131, 132, 133, 148, 149, 179, 184 |
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|- |
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|[[Wart|Common warts]] |
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|1, 2, 4, 27 |
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|- |
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|[[Wart|Warts]] of meat, poultry, and fish handlers |
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|2, 7 |
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|1, 3, 4, 10, 28 |
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|- |
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|[[Wart|Flat and intermediate warts]] |
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|3, 10 |
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|27, 28, 38, 41, 49, 75, 76, 126 |
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|- |
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|[[Epidermodysplasia verruciformis]] |
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|5, 8, 9, 12, 14, 15, 17 |
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|19, 20, 21, 22, 23, 24, 25, 36, 37, 38, 47, 49, 50, 75, 93 |
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|- |
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|[[Condylomata acuminata]] |
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|6, 11 |
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|16, 18, 26, 31, 33, 35, 40, 42, 43, 44, 45, 51, 52, 53, 54, 55, 56, 58, 59, 66, 68, 70, 153, 175, 178, 180, 200, 201, 202 |
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|- |
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|[[Intraepithelial neoplasia]] |
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| |
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| |
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|Intraepithelial neoplasia (unspecified) |
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| |
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|26, 30, 34, 39, 40, 53, 57, 59, 61, 62, 67, 68, 69, 71, 81, 83 |
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|- |
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|Intraepithelial neoplasia (low-grade) |
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|6, 11 |
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|16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 54, 61, 70, 72, 74 |
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|- |
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|Intraepithelial neoplasia (high-grade) |
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|16, 18 |
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|6, 11, 31, 33, 34, 35, 39, 42, 44, 45, 51, 52, 56, 58, 66, 67 |
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|- |
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|[[Cervical carcinoma]] |
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|16, 18 |
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|26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 67, 68, 73, 82 |
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|- |
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|Recurrent [[respiratory papillomatosis]] |
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|6, 11 |
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|16, 18, 31, 33, 35, 39 |
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|- |
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|Focal epithelial hyperplasia of Heck |
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|13, 32 |
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|18, 33, 45 |
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|- |
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|[[Conjunctival papilloma|Conjunctival papillomas]] and [[Conjunctival carcinoma|carcinomas]] |
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|6, 11, 16 |
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| |
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|} |
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== Prevention == |
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=== Vaccination === |
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{| class="wikitable" |
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! rowspan="3" |Vaccine |
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! rowspan="3" |Genotypes |
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! colspan="6" |Schedule |
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|- |
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! colspan="3" |Girls and Women |
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! colspan="3" |Boys and Men |
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|- |
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!9 to 15 years |
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!≥15 years |
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!Immunocompromised |
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!9 to 15 years |
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!≥15 years |
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!Immunocompromised |
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|- |
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|Cervarix |
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|16, 18 |
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| rowspan="3" |2 or 3 dose |
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| rowspan="3" |3 dose |
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| rowspan="3" |3 dose |
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| colspan="3" |not indicated |
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|- |
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|Gardasil |
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|6, 11, 16, 18 |
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| rowspan="2" |2 or 3 dose |
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| rowspan="2" |3 dose |
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| rowspan="2" |3 dose |
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|- |
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|Gardasil-9 |
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|6, 11, 16, 18, 31, 33, 45, 51, 58 |
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|} |
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* Two-dose schedule |
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** Only indicated for children aged at least 9 to less than 15 years |
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** Given at 0 and 6 months |
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* Three-dose schedule |
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** Indicated for everyone, including children 9 years and older, men and women 15 years and older and immunocompromised people |
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** Given at 0, 2, and 6 months |
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[[Category:DNA viruses]] |
[[Category:DNA viruses]] |
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Revision as of 14:42, 14 August 2020
Background
- Oncogenic double-stranded DNA virus in the Papillomaviridae family
Clinical Manifestations
- Most commonly associated with warts (including genital warts), cervical cancer, and penile cancer
| Disease | Common Genotypes | Uncommon Genotypes |
|---|---|---|
| Plantar warts | 1, 2, 27 | 4, 26, 28, 29, 41, 57, 63, 65, 77, 117, 125, 128, 129, 130, 131, 132, 133, 148, 149, 179, 184 |
| Common warts | 1, 2, 4, 27 | |
| Warts of meat, poultry, and fish handlers | 2, 7 | 1, 3, 4, 10, 28 |
| Flat and intermediate warts | 3, 10 | 27, 28, 38, 41, 49, 75, 76, 126 |
| Epidermodysplasia verruciformis | 5, 8, 9, 12, 14, 15, 17 | 19, 20, 21, 22, 23, 24, 25, 36, 37, 38, 47, 49, 50, 75, 93 |
| Condylomata acuminata | 6, 11 | 16, 18, 26, 31, 33, 35, 40, 42, 43, 44, 45, 51, 52, 53, 54, 55, 56, 58, 59, 66, 68, 70, 153, 175, 178, 180, 200, 201, 202 |
| Intraepithelial neoplasia | ||
| Intraepithelial neoplasia (unspecified) | 26, 30, 34, 39, 40, 53, 57, 59, 61, 62, 67, 68, 69, 71, 81, 83 | |
| Intraepithelial neoplasia (low-grade) | 6, 11 | 16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 54, 61, 70, 72, 74 |
| Intraepithelial neoplasia (high-grade) | 16, 18 | 6, 11, 31, 33, 34, 35, 39, 42, 44, 45, 51, 52, 56, 58, 66, 67 |
| Cervical carcinoma | 16, 18 | 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 67, 68, 73, 82 |
| Recurrent respiratory papillomatosis | 6, 11 | 16, 18, 31, 33, 35, 39 |
| Focal epithelial hyperplasia of Heck | 13, 32 | 18, 33, 45 |
| Conjunctival papillomas and carcinomas | 6, 11, 16 |
Prevention
Vaccination
| Vaccine | Genotypes | Schedule | |||||
|---|---|---|---|---|---|---|---|
| Girls and Women | Boys and Men | ||||||
| 9 to 15 years | ≥15 years | Immunocompromised | 9 to 15 years | ≥15 years | Immunocompromised | ||
| Cervarix | 16, 18 | 2 or 3 dose | 3 dose | 3 dose | not indicated | ||
| Gardasil | 6, 11, 16, 18 | 2 or 3 dose | 3 dose | 3 dose | |||
| Gardasil-9 | 6, 11, 16, 18, 31, 33, 45, 51, 58 | ||||||
- Two-dose schedule
- Only indicated for children aged at least 9 to less than 15 years
- Given at 0 and 6 months
- Three-dose schedule
- Indicated for everyone, including children 9 years and older, men and women 15 years and older and immunocompromised people
- Given at 0, 2, and 6 months
