Mpox virus: Difference between revisions
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==Background== |
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===Microbiology=== |
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*Monkeypox virus (MPXV) is in the genus ''Orthopoxvirus'' and family ''Poxviridae'' |
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===Epidemiology=== |
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*Zoonotic disease endemic to west and central Africa |
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**Hosts include non-human primates and prairie dogs, squirrels, and possibly other rodents |
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**Endemic countries include DRC (most common), Liberia, Ivory Coast, Sierra Leone, Nigeria, Benin, Cameroon, Gabon, and South Sudan |
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*Human infection is associated with animal trapping, hunting, and skinning, and other exposures to animals including bites, feces, urine, or respiratory droplets |
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**Global outbreaks may happen with the global trafficking in exotic pets |
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*Human-to-human transmission possible, but less than smallpox |
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==Clinical Manifestations== |
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*Clinically indistinguishible from smallpox, though may have much more pronounced lymphadenopathy |
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*Incubation period about [[Usual incubation period::12 days]] |
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*[[Causes::Fever]], [[Causes::rash]], [[Causes::lymphadenopathy]] (cervical, submandibular, and sublingual) |
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*Mortality 1-10% (per WHO) |
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==Management== |
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===Post-exposure prophylaxis=== |
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*??smallpox vaccine?? |
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[[Category:Poxviridae]] |
[[Category:Poxviridae]] |
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Revision as of 13:43, 5 August 2020
Background
Microbiology
- Monkeypox virus (MPXV) is in the genus Orthopoxvirus and family Poxviridae
Epidemiology
- Zoonotic disease endemic to west and central Africa
- Hosts include non-human primates and prairie dogs, squirrels, and possibly other rodents
- Endemic countries include DRC (most common), Liberia, Ivory Coast, Sierra Leone, Nigeria, Benin, Cameroon, Gabon, and South Sudan
- Human infection is associated with animal trapping, hunting, and skinning, and other exposures to animals including bites, feces, urine, or respiratory droplets
- Global outbreaks may happen with the global trafficking in exotic pets
- Human-to-human transmission possible, but less than smallpox
Clinical Manifestations
- Clinically indistinguishible from smallpox, though may have much more pronounced lymphadenopathy
- Incubation period about 12 days
- Fever, rash, lymphadenopathy (cervical, submandibular, and sublingual)
- Mortality 1-10% (per WHO)
Management
Post-exposure prophylaxis
- ??smallpox vaccine??
References
- ^ Emily A Siegrist, Joseph Sassine. Antivirals With Activity Against Mpox: A Clinically Oriented Review. Clinical Infectious Diseases. 2022;76(1):155-164. doi:10.1093/cid/ciac622.
