Epstein-Barr virus: Difference between revisions
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= Epstein-Barr virus (EBV) = |
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* '''Anti-VCA''' (viral capsid antigens): most useful |
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* '''Monospot''' test: cross-reacts with many other conditions, and is often falsely negative in children |
* '''Monospot''' test: cross-reacts with many other conditions, and is often falsely negative in children |
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== Serology in immunocompetent hosts == |
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== Serology in EBV-associated diseases == |
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[[Category:Herpesviridae]] |
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Revision as of 11:56, 13 August 2019
Diagnosis
- Anti-VCA (viral capsid antigens): most useful
- Anti-VCA IgM: appears early and disappears within 4 to 6 weeks
- Anti-VCA IgG: appears in acute phase, peaks at 2 to 4 weeks, then declines but remains positive for life
- Anti-EA (early antigen) IgG: appears in acute phase and falls to undetectable within 3 to 6 months (but may persist for years)
- Least useful test
- Anti-EBNA (EBV nuclear antigen): negative during acute phase converts after 2 to 4 months and stays positive for life
- Monospot test: cross-reacts with many other conditions, and is often falsely negative in children
Serology in immunocompetent hosts
| VCa-IgM | VCA-IgG | EBNA-IgG | Interpretation |
|---|---|---|---|
| – | – | – | Susceptible |
| – | – | + | Past infection or non-specific |
| – | + | – | Acute or past infection |
| – | + | + | Past infection |
| + | – | – | Acute infection or non-specific |
| + | – | + | ?? |
| + | + | – | Acute infection |
| + | + | + | Late primary infection or reactivation |
Serology in EBV-associated diseases
| Disease | VCA-IgM | VCA-IgG | VCA-IgA | EA(D)-IgG | EA(R)-IgG | EA-IgA | EBNA-IgG |
|---|---|---|---|---|---|---|---|
| Chronic active infection | ± | ++ | ± | + | ++ | – | ± |
| Burkitt lymphoma | – | ++ | – | ± | ++ | – | + |
| ENT carcinoma | – | ++ | + | ++ | ± | + | + |
| Hodgkin lymphoma | – | ++ | – | + | – | – | + |
| Reactivation | ± | ++ | ± | + | ± | ± | ± |
References
- ^ Massimo De Paschale. Serological diagnosis of Epstein-Barr virus infection: Problems and solutions. World Journal of Virology. 2012;1(1):31. doi:10.5501/wjv.v1.i1.31.
