Isopropanol toxicity: Difference between revisions
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* The alcohol is metabolized by alcohol dehydrogenase to acetone, causing ketosis and an osmolar gap, but '''not''' an elevated anion gap |
* The alcohol is metabolized by alcohol dehydrogenase to acetone, causing ketosis and an osmolar gap, but '''not''' an elevated anion gap |
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== Clinical |
== Clinical Manifestations == |
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* CNS depression |
* CNS depression |
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Latest revision as of 01:33, 14 July 2020
Summary
Definition
- Also known as isopropyl alcohol, or rubbing alcohol
Pathophysiology
- The alcohol is metabolized by alcohol dehydrogenase to acetone, causing ketosis and an osmolar gap, but not an elevated anion gap
Clinical Manifestations
- CNS depression
- Acetone-fruity breath
- Shock, pulmonary edema, hemorrhagic tracheobronchitis
Investigations
- Glucose, to rule out hypoglycemia as a cause of CNS depression
- Acetaminophen and aspirin levels for coingestion
- ECG for QTc
- Osmolar gap, will be high
- Electrolytes, creatinine, urea
- Urea measures as elevated with isopropyl alcohol
- Serum isopropyl alcohol and acetone levels
Management
- ABCs, supportive care
- No role for fomepizole or ethanol
