John Cunningham virus: Difference between revisions
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* CNS infection with JC virus, usually in the context of HIV infection |
* CNS infection with JC virus, usually in the context of HIV infection |
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==Background== |
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===Epidemiology=== |
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* HIV patients |
* HIV patients |
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==Clinical Presentation== |
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* '''Classic PML''' |
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** Subacute onset of focal central neurological lesions |
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** Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI |
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* '''PML-IRIS''' |
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** Focal central neurological lesions following immune recovery |
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** Contrast enhancing lesions with or without mass effect on MRI |
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* '''JCV granule cell neuropathy''' |
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** Chronic cerebellar dysfunction |
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** Cerebellar atrophy on MRI |
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* '''JCV encephalitis''' |
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** Subacute onset of encephalopathy |
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** Cortical lesions on MRI |
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* '''JCV meningitis''' |
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** Chronic headaches |
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** Ventriculomegaly on MRI |
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* MRI head: white matter changes |
* MRI head: white matter changes |
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==Diagnosis== |
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* JC virus PCR |
* JC virus PCR |
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==Treatment== |
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* Antiretroviral therapy for HIV |
* Antiretroviral therapy for HIV |
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Revision as of 18:50, 23 May 2020
- CNS infection with JC virus, usually in the context of HIV infection
Background
Epidemiology
- HIV patients
Clinical Presentation
- Classic PML
- Subacute onset of focal central neurological lesions
- Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI
- PML-IRIS
- Focal central neurological lesions following immune recovery
- Contrast enhancing lesions with or without mass effect on MRI
- JCV granule cell neuropathy
- Chronic cerebellar dysfunction
- Cerebellar atrophy on MRI
- JCV encephalitis
- Subacute onset of encephalopathy
- Cortical lesions on MRI
- JCV meningitis
- Chronic headaches
- Ventriculomegaly on MRI
Investigations
- MRI head: white matter changes
Diagnosis
- JC virus PCR
Treatment
- Antiretroviral therapy for HIV
