HIV elite controllers: Difference between revisions

Latest revision as of 00:13, 8 February 2020

Variably defined, but the common thread is that of someone who maintains an undetectable viral load despite not being on treatment
One possible definition is someone with 3 or more undetectable viral loads over at least 12 months

Unclear; likely multifactorial
Host genetics
- HLA type
- Heterozygous CCR5 deletion mutation
- Mannose-binding lectin alleles
- Tumour necrosis factor c2 microsatellite alleles
- Gc vitamin D-binding factor alleles
Host immunity
- Effective cytotoxic T-cell responses
- Secretion of CD8 antiviral factor
- Secretion of chemokines that block HIV entry co-receptors (CCR5 and CXCR4)
- Maintenance of functional lymphoid tissue architecture
Virus
- Attenuated strain of HIV

@@ Line 8: / Line 8: @@
 * Exact prevalence depends on the definition
 * Many elite controllers will eventually have breakthrough
+=== Pathophysiology ===
+* Unclear; likely multifactorial
+* Host genetics
+** HLA type
+** Heterozygous CCR5 deletion mutation
+** Mannose-binding lectin alleles
+** Tumour necrosis factor c2 microsatellite alleles
+** Gc vitamin D-binding factor alleles
+* Host immunity
+** Effective cytotoxic T-cell responses
+** Secretion of CD8 antiviral factor
+** Secretion of chemokines that block HIV entry co-receptors (CCR5 and CXCR4)
+** Maintenance of functional lymphoid tissue architecture
+* Virus
+** Attenuated strain of [[HIV]]
 == Management ==