Adenovirus: Difference between revisions
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== Background == |
== Background == |
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=== Microbiology === |
=== Microbiology === |
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* Non-enveloped double-stranded DNA virus |
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* Seven species with multiple serotypes |
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=== Epidemiology === |
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* Transmitted by droplets or aerosol |
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== Clinical Presentation == |
== Clinical Presentation == |
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* Common cause of upper respiratory infections in immunocompetent people |
* Common cause of upper respiratory infections in immunocompetent people |
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* Can also cause acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted) |
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* In cellular immunodeficiency, can cause severe disease |
* In cellular immunodeficiency or neonates, can cause severe disease |
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** Disseminated disease |
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** Hemorrhagic cystitis in hematopoietic stem cell transplant |
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== Diagnosis == |
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* Typically by PCR |
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* May see smudge cells on histology (but not specific) |
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== Management == |
== Management == |
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Revision as of 21:04, 27 January 2020
Background
Microbiology
- Non-enveloped double-stranded DNA virus
- Seven species with multiple serotypes
Epidemiology
- Transmitted by droplets or aerosol
Clinical Presentation
- Common cause of upper respiratory infections in immunocompetent people
- Can also cause acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted)
- In cellular immunodeficiency or neonates, can cause severe disease
- Disseminated disease
- Hemorrhagic cystitis in hematopoietic stem cell transplant
Diagnosis
- Typically by PCR
- May see smudge cells on histology (but not specific)
Management
- Only current effective treatment is cidofovir
