Acute generalized exanthematous pustulosis: Difference between revisions

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* Also known as a pustular drug eruption or toxic pustuloderma
* Also known as a pustular drug eruption or toxic pustuloderma
* Typically triggered by medications but can also occur after a spider bite
* Typically triggered by medications
** Antibiotics (especially β-lactams) are most common trigger by far, followed by PPIs, NSAIDs, and herbal medicine
* Characteristic rash is diffuse, erythematous, with many pinpoint pustules
* Characteristic rash is diffuse, erythematous, with many pinpoint pustules
** Typically starts in face or intertriginous areas, then spreads centrally
** Typically starts in face or intertriginous areas, then spreads centrally

Latest revision as of 12:21, 2 December 2019

  • Also known as a pustular drug eruption or toxic pustuloderma
  • Typically triggered by medications
    • Antibiotics (especially β-lactams) are most common trigger by far, followed by PPIs, NSAIDs, and herbal medicine
  • Characteristic rash is diffuse, erythematous, with many pinpoint pustules
    • Typically starts in face or intertriginous areas, then spreads centrally
    • Can involve palms and soles but not mucosa
    • May be followed by desquamation
  • Can also have systemic symptoms
  • May have mild liver enzyme abnormalities