Β-lactam resistance: Difference between revisions
From IDWiki
Β-lactam resistance
No edit summary |
(Added NDM) |
||
| Line 14: | Line 14: | ||
* Class C: AmpC ß-lactamases |
* Class C: AmpC ß-lactamases |
||
* Class D: OXA ß-lactamases |
* Class D: OXA ß-lactamases |
||
| + | |||
| + | == Specific ß-lactamases == |
||
| + | === NDM-1 === |
||
| + | * Broad-spectrum metallo-beta-lactamase and carbapenemase |
||
| + | * Can be treated empirically with [[ceftazadime-avibactam]] and [[aztreonam]] +/- [[colistin]] |
||
[[Category:Antibiotics]] |
[[Category:Antibiotics]] |
||
Revision as of 18:33, 15 November 2019
Mechanisms
- ß-lactamase production: enzymatic breakdown of beta lactam antibiotic
- Penicillin binding protein mutations (e.g. MRSA)
- Efflux pump mutations
- Porin channel mutations that reduce antibiotic influx
Ambler Classification of ß-lactamases
- Based on amino acid sequences rather than function
- Classes A, C, and D are serine ß-lactamases
- Class A: original active-site serine ß-lactamases
- Class B: original metallo-ß-lactamases
- Class C: AmpC ß-lactamases
- Class D: OXA ß-lactamases
Specific ß-lactamases
NDM-1
- Broad-spectrum metallo-beta-lactamase and carbapenemase
- Can be treated empirically with ceftazadime-avibactam and aztreonam +/- colistin
