Pseudomonas aeruginosa: Difference between revisions
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Pseudomonas aeruginosa
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== Background == |
== Background == |
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=== Microbiology === |
=== Microbiology === |
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* [[Has oxidase test::Oxidase-positive]], non-fermenting [[Has Gram stain::Gram-negative]] [[Has cell shape::bacillus]] |
* [[Has oxidase test::Oxidase-positive]], [[Has fermentation::non-fermenting]] [[Has Gram stain::Gram-negative]] [[Has cell shape::bacillus]] |
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=== Mechanisms of Resistance === |
=== Mechanisms of Resistance === |
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Revision as of 14:38, 9 November 2019
Background
Microbiology
Mechanisms of Resistance
- Broad intrinsic and acquired antibiotic resistance
- Membrane impermeability
- MexAB-OprM efflux pump
- Acquired mutations
- Inducible AmpC β-lactamase
- Plasmid sharing
Epidemiology
- Loves moist and wet environments
- Causes healthcare-associated infections
- UTI, SSI, bacteremia, HAP, VAP
- Especially common in cystic fibrosis
Treatment
- Refer to antipseudomonal antibiotics for specific treatment options
- Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection
