Ganciclovir: Difference between revisions
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* Inhibits all [[human herpesviruses]] by inhibiting DNA polymerase |
* Inhibits all [[human herpesviruses]] by inhibiting DNA polymerase |
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* Resistance in [[CMV]] is conferred by mutations of UL97 kinase, which is required in order to phosphorylate ganciclovir into its active form |
* Resistance in [[CMV]] is conferred by mutations of UL97 kinase, which is required in order to phosphorylate ganciclovir into its active form |
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* Oral bioavailability 6-8% |
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Revision as of 01:49, 24 October 2019
- Guanosine nucleoside analogue similar to acyclovir
- Inhibits all human herpesviruses by inhibiting DNA polymerase
- Resistance in CMV is conferred by mutations of UL97 kinase, which is required in order to phosphorylate ganciclovir into its active form
- Oral bioavailability 6-8%
