Pyrimethamine: Difference between revisions
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** GI intolerance |
** GI intolerance |
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** Other: rash, hepatitis, headache, dizziness, insomnia |
** Other: rash, hepatitis, headache, dizziness, insomnia |
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* Monitoring |
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** CBC q2d initially, then decreasing frequency |
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Revision as of 14:03, 19 September 2019
- Antimicrobial that inhibits the reduction of dihydrofolic to tetrahydrofolic acid
- Indications include toxoplasmosis and malaria
- Major adverse effects is bone marrow suppression, so need to monitor CBC
- Pancytopenia, which is reversible with leucovorin
- GI intolerance
- Other: rash, hepatitis, headache, dizziness, insomnia
- Monitoring
- CBC q2d initially, then decreasing frequency
