Pyrimethamine: Difference between revisions
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* Antimicrobial that inhibits the reduction of dihydrofolic to tetrahydrofolic acid |
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* Indications include [[Is treatment for::toxoplasmosis]] and [[Is treatment for::malaria]] |
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** Pancytopenia, which is reversible with leucovorin |
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** GI intolerance |
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** Other: rash, hepatitis, headache, dizziness, insomnia |
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Revision as of 13:54, 19 September 2019
- Antimicrobial that inhibits the reduction of dihydrofolic to tetrahydrofolic acid
- Indications include toxoplasmosis and malaria
- Major adverse effects is bone marrow suppression, so need to monitor CBC
- Pancytopenia, which is reversible with leucovorin
- GI intolerance
- Other: rash, hepatitis, headache, dizziness, insomnia
