Pseudomonas aeruginosa: Difference between revisions
From IDWiki
Pseudomonas aeruginosa
(→) |
No edit summary |
||
| Line 1: | Line 1: | ||
= Microbiology = |
== Microbiology == |
||
* Oxidase-positive, non-fermenting Gram negative bacillus |
* Oxidase-positive, non-fermenting Gram negative bacillus |
||
= Mechanisms of Resistance = |
== Mechanisms of Resistance == |
||
* Broad intrinsic and acquired antibiotic resistance |
* Broad intrinsic and acquired antibiotic resistance |
||
| Line 12: | Line 12: | ||
* Plasmid sharing |
* Plasmid sharing |
||
= Environment and Infections = |
== Environment and Infections == |
||
* Loves moist and wet environments |
* Loves moist and wet environments |
||
| Line 19: | Line 19: | ||
** Especially common in cystic fibrosis |
** Especially common in cystic fibrosis |
||
= Treatment = |
== Treatment == |
||
* See [[Antipseudomonal antibiotics]] |
* See [[Antipseudomonal antibiotics]] |
||
Revision as of 15:25, 17 August 2019
Microbiology
- Oxidase-positive, non-fermenting Gram negative bacillus
Mechanisms of Resistance
- Broad intrinsic and acquired antibiotic resistance
- Membrane impermeability
- MexAB-OprM efflux pump
- Acquired mutations
- Inducible AmpC β-lactamase
- Plasmid sharing
Environment and Infections
- Loves moist and wet environments
- Causes healthcare-associated infections
- UTI, SSI, bacteremia, HAP, VAP
- Especially common in cystic fibrosis
Treatment
- See Antipseudomonal antibiotics
- Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection
References
- ^ D. M. Livermore. Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?. Clinical Infectious Diseases. 2002;34(5):634-640. doi:10.1086/338782.
