Drug-resistant tuberculosis: Difference between revisions
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= Definition = |
== Definition == |
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* [[Tuberculosis]] infection that is resistant to both first-line drugs, isoniazid and rifampin |
* [[Tuberculosis]] infection that is resistant to both first-line drugs, isoniazid and rifampin |
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= Management = |
== Management == |
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* 8 months of an intensive four-drug regimen that includes any four drugs to which it is susceptible, in order of preference: |
* 8 months of an intensive four-drug regimen that includes any four drugs to which it is susceptible, in order of preference: |
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Revision as of 15:24, 17 August 2019
Definition
- Tuberculosis infection that is resistant to both first-line drugs, isoniazid and rifampin
Management
- 8 months of an intensive four-drug regimen that includes any four drugs to which it is susceptible, in order of preference:
- Any first-line agents to which it is still susceptible
- A fluoroquinolone (except ciprofloxacin)
- An injectable: kanamycin, or other parenteral agent
- Other second-line agents, starting with ethionamide
- Followed by 12 months of a less intensive regimen (at least three effective drugs), for a total of at least 20 months
