Anti-NMDAR encephalitis: Difference between revisions
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Created page with "== Background == * Relatively common cause of autoimmune encephalitis * More common in women of childbearing age (18 to 45) * Associated with ovarian teratoma and sometimes other tumours == Clinical Manifestations == * Myriad symptoms * Subacute presentation that can be organised into: ** Prodromal phase, with flu-like illness last weeks up to a few months ** Psychotic phase, with variable psychiatric manifestations, with fairly rapid onset sometimes prompting adm..." |
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* More common in women of childbearing age (18 to 45) |
* More common in women of childbearing age (18 to 45) |
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* Associated with ovarian teratoma and sometimes other tumours |
* Associated with ovarian teratoma and sometimes other tumours |
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* Pathophysiology is from the production of IgG antibodies targetting NMDA receptors |
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== Clinical Manifestations == |
== Clinical Manifestations == |
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** Hyperkinetic phase, usually oro-lingual dyskinesia (lip-smacking, tongue protrusion, jaw movements), but can be a variety of movement disorders |
** Hyperkinetic phase, usually oro-lingual dyskinesia (lip-smacking, tongue protrusion, jaw movements), but can be a variety of movement disorders |
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** Recover phase |
** Recover phase |
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== Diagnosis == |
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* Anti-NMDAR IgG antibodies, detected by indirect immunofluorescence assay in the serum and the CSF |
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Latest revision as of 18:15, 10 April 2026
Background
- Relatively common cause of autoimmune encephalitis
- More common in women of childbearing age (18 to 45)
- Associated with ovarian teratoma and sometimes other tumours
- Pathophysiology is from the production of IgG antibodies targetting NMDA receptors
Clinical Manifestations
- Myriad symptoms
- Subacute presentation that can be organised into:
- Prodromal phase, with flu-like illness last weeks up to a few months
- Psychotic phase, with variable psychiatric manifestations, with fairly rapid onset sometimes prompting admission to psychiatric units
- Unresponsive phase
- Hyperkinetic phase, usually oro-lingual dyskinesia (lip-smacking, tongue protrusion, jaw movements), but can be a variety of movement disorders
- Recover phase
Diagnosis
- Anti-NMDAR IgG antibodies, detected by indirect immunofluorescence assay in the serum and the CSF
