Multicentric Castleman disease: Difference between revisions
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* Fevers and chills |
* Fevers and chills |
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* Generalized lymphadenopathy |
* Generalized lymphadenopathy (universal) |
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* Hepatomegaly and/or splenomegaly |
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* Edema, pleural effusions, anasarca |
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* May have thrombocytopenia, anemia, kidney disease, polyclonal hypergammaglobulinemia, hypoalbuminemia |
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* Can progress to [[large B cell lymphoma]] |
* Can progress to [[large B cell lymphoma]] |
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== Diagnosis == |
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* Made on lymph node biopsy, with exclusion of other potential causes |
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[[Category:Hematology]] |
[[Category:Hematology]] |
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Latest revision as of 18:02, 23 July 2025
Background
- Rare lymphoproliferative disorder
- Mostly associated with HHV-8, but not necessarily specific to HIV
- However, some cases are idiopathic
Clinical Manifestations
- Fevers and chills
- Generalized lymphadenopathy (universal)
- Hepatomegaly and/or splenomegaly
- Edema, pleural effusions, anasarca
- May have thrombocytopenia, anemia, kidney disease, polyclonal hypergammaglobulinemia, hypoalbuminemia
- Can progress to large B cell lymphoma
Diagnosis
- Made on lymph node biopsy, with exclusion of other potential causes
