Meropenem-vaborbactam: Difference between revisions
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* Carbapenem-resistant infection with [[Enterobacterales]]: 4 g IV every 8 hours |
* Carbapenem-resistant infection with [[Enterobacterales]]: 4 g IV every 8 hours |
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* Complicated [[urinary tract infection]]: 4 g IV every 8 hours for 5 to 14 days |
* Complicated [[urinary tract infection]]: 4 g IV every 8 hours for 5 to 14 days |
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=== Renal Dosing === |
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{| class="wikitable" |
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!eGFR |
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!Dose |
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|- |
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|≥50 |
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|4 g IV every 8 hours (normal dose) |
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|- |
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|30 to 49 |
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|2 g IV every 8 hours |
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|- |
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|15 to 29 |
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|2 g IV every 12 hours |
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|- |
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|<15 |
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|1 g IV every 12 hours |
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|- |
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|IHD |
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|1 g IV every 12 hours |
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|- |
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|PD |
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|1 g IV every 12 hours |
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|- |
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|CRRT |
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|2 g IV every 8 hours |
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|} |
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== Safety == |
== Safety == |
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Latest revision as of 16:09, 27 June 2025
Background
Mechanism of Activity
- Vaborbactam is active against KPC carbapenemases
Dosing
- Carbapenem-resistant infection with Enterobacterales: 4 g IV every 8 hours
- Complicated urinary tract infection: 4 g IV every 8 hours for 5 to 14 days
Renal Dosing
| eGFR | Dose |
|---|---|
| ≥50 | 4 g IV every 8 hours (normal dose) |
| 30 to 49 | 2 g IV every 8 hours |
| 15 to 29 | 2 g IV every 12 hours |
| <15 | 1 g IV every 12 hours |
| IHD | 1 g IV every 12 hours |
| PD | 1 g IV every 12 hours |
| CRRT | 2 g IV every 8 hours |
Safety
Monitoring
- Seizures, thrombocytopenia, drug interaction with valproic acid
