Calciphylaxis: Difference between revisions
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(Created page with "== Background == * Syndrome of skin ischemia and necrosis in the context of end-stage renal disease on dialysis * Rarely occurs in patients without ESRD, particularly with hyperparathyroidism, malignancy, alcoholic liver disease, and connective tissue diseases Category:Nephrology") |
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* Syndrome of skin ischemia and necrosis in the context of [[end-stage renal disease]] on [[dialysis]] |
* Syndrome of skin ischemia and necrosis in the context of [[end-stage renal disease]] on [[dialysis]] |
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* Rarely occurs in patients without ESRD, particularly with hyperparathyroidism, malignancy, alcoholic liver disease, and connective tissue diseases |
* Rarely occurs in patients without ESRD, particularly with hyperparathyroidism, malignancy, alcoholic liver disease, and connective tissue diseases |
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== Clinical Manifestations == |
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* Presents with necrotic ulcerations basically anywhere |
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* Lesions may start as a purplish, painful, subcutaneous nodules or plaques, indurations, or livedo reticularis |
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== Diagnosis == |
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* Mostly clinical |
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* No specific laboratory abnormalities |
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* Biopsy may show dermo-hypodermal and pannicular arteriolar calcification, subintimal fibrosis, and thrombotic occlusion |
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== Management == |
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* Continue dialysis |
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* Wound care and pain management |
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* Treat infections as indicated |
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* Consider treating hyperphosphatemia (using [[sevelamer]] or [[lanthanum]]) |
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* Consider treating elevated PTH with [[cinacalcet]] |
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[[Category:Nephrology]] |
[[Category:Nephrology]] |
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Latest revision as of 20:18, 7 January 2025
Background
- Syndrome of skin ischemia and necrosis in the context of end-stage renal disease on dialysis
- Rarely occurs in patients without ESRD, particularly with hyperparathyroidism, malignancy, alcoholic liver disease, and connective tissue diseases
Clinical Manifestations
- Presents with necrotic ulcerations basically anywhere
- Lesions may start as a purplish, painful, subcutaneous nodules or plaques, indurations, or livedo reticularis
Diagnosis
- Mostly clinical
- No specific laboratory abnormalities
- Biopsy may show dermo-hypodermal and pannicular arteriolar calcification, subintimal fibrosis, and thrombotic occlusion
Management
- Continue dialysis
- Wound care and pain management
- Treat infections as indicated
- Consider treating hyperphosphatemia (using sevelamer or lanthanum)
- Consider treating elevated PTH with cinacalcet
