Immune reconstitution inflammatory syndrome: Difference between revisions
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* Varies by underlying infection |
* Varies by underlying infection |
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* Onset usually a month following starting antiretrovirals, but can be up to a year |
* Onset usually a month following starting antiretrovirals, but can be up to a year |
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** Mostly within 4 to 8 weeks of starting or changing ART, but with a range from 3 days to several months (or in case reports up to years) |
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[[Category:HIV]] |
[[Category:HIV]] |
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Revision as of 16:03, 15 October 2024
Background
- Two main forms:
- Unmasking: an underlying, previously undiagnosed infection becomes clinically apparent following immune reconstitution
- Paradoxical: a diagnosed and treated infection worsens following immune reconstitution
Microbiology
- Mycobacteria
- Fungi
- Viruses
Risk Factors
- High viral load
- Low CD4 count
Clinical Manifestations
- Varies by underlying infection
- Onset usually a month following starting antiretrovirals, but can be up to a year
- Mostly within 4 to 8 weeks of starting or changing ART, but with a range from 3 days to several months (or in case reports up to years)
