Drug-resistant tuberculosis: Difference between revisions

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= Definition =
= Multi-drug-resistant tuberculosis (MDR-TB) =


* [[Tuberculosis]] infection that is resistant to both first-line drugs, isoniazid and rifampin
== Definition ==


= Management =
* [Tuberculosis](Tuberculosis (TB).md) infection that is resistant to both first-line drugs, isoniazid and rifampin

== Management ==


* 8 months of an intensive four-drug regimen that includes any four drugs to which it is susceptible, in order of preference:
* 8 months of an intensive four-drug regimen that includes any four drugs to which it is susceptible, in order of preference:
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** Other second-line agents, starting with ethionamide
** Other second-line agents, starting with ethionamide
* Followed by 12 months of a less intensive regimen (at least three effective drugs), for a total of at least 20 months
* Followed by 12 months of a less intensive regimen (at least three effective drugs), for a total of at least 20 months

[[Category:TB]]

Revision as of 03:24, 15 August 2019

Definition

  • Tuberculosis infection that is resistant to both first-line drugs, isoniazid and rifampin

Management

  • 8 months of an intensive four-drug regimen that includes any four drugs to which it is susceptible, in order of preference:
    • Any first-line agents to which it is still susceptible
    • A fluoroquinolone (except ciprofloxacin)
    • An injectable: kanamycin, or other parenteral agent
    • Other second-line agents, starting with ethionamide
  • Followed by 12 months of a less intensive regimen (at least three effective drugs), for a total of at least 20 months