Valganciclovir: Difference between revisions
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== Background == |
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* Valine ester of [[ganciclovir]] with much higher oral bioavailability (70%) |
* Valine ester of [[ganciclovir]] with much higher oral bioavailability (70%) |
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* Indications: {{#ask: [[Is treated by::valganciclovir]] | default=none}} |
* Indications: {{#ask: [[Is treated by::valganciclovir]] | default=none}} |
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== Dosing == |
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* [[CMV after solid organ transplantation|CMV prophylaxis in solid organ transplant]]: 900 mg p.o. daily |
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* Mild-to-moderate [[CMV after solid organ transplantation|CMV disease in solid organ transplant]]: 900 mg p.o. twice daily |
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* [[CMV after hematopoietic stem cell transplantation|CMV viremia in hematopoietic stem cell transplant]]: 900 mg p.o. twice daily for 7 to 14 days followed by once daily until negative PCR |
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=== Renal Dosing === |
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{| class="wikitable" |
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!CrCl |
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!Induction or Treatment |
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!Maintenance or Prophylaxis |
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|- |
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|≥60 |
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|900 mg twice daily |
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|900 mg once daily |
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|- |
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|40 to 59 |
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|450 mg twice daily |
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|450 mg once daily |
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|- |
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|25 to 39 |
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|450 mg once daily |
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|450 mg every 2 days |
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|- |
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|10 to 24 |
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|450 mg every 2 days |
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|450 mg twice weekly |
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|- |
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|<10 |
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|Not recommended; may consider using oral solution 200 mg 3 times weekly |
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|Not recommended; may consider using oral solution 100 mg 3 times weekly |
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|} |
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== Safety == |
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=== Adverse Effects === |
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* Long list |
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* Anemia, thrombocytopenia, and neutropenia |
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[[Category:Antivirals]] |
[[Category:Antivirals]] |
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Latest revision as of 21:59, 22 February 2024
Background
- Valine ester of ganciclovir with much higher oral bioavailability (70%)
- Indications: CMV after hematopoietic stem cell transplantation, CMV after solid organ transplantation, Congenital CMV, Cytomegalovirus, Herpesviridae
Dosing
- CMV prophylaxis in solid organ transplant: 900 mg p.o. daily
- Mild-to-moderate CMV disease in solid organ transplant: 900 mg p.o. twice daily
- CMV viremia in hematopoietic stem cell transplant: 900 mg p.o. twice daily for 7 to 14 days followed by once daily until negative PCR
Renal Dosing
| CrCl | Induction or Treatment | Maintenance or Prophylaxis |
|---|---|---|
| ≥60 | 900 mg twice daily | 900 mg once daily |
| 40 to 59 | 450 mg twice daily | 450 mg once daily |
| 25 to 39 | 450 mg once daily | 450 mg every 2 days |
| 10 to 24 | 450 mg every 2 days | 450 mg twice weekly |
| <10 | Not recommended; may consider using oral solution 200 mg 3 times weekly | Not recommended; may consider using oral solution 100 mg 3 times weekly |
Safety
Adverse Effects
- Long list
- Anemia, thrombocytopenia, and neutropenia
