Cabotegravir/rilpivirine: Difference between revisions
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(Created page with "* Long-acting injectable medication used to treat HIV * Studied after viral suppression with oral CAB/RPV, but this is not likely to be necessary * Dosing ** 600 mg/900 mg IM on week 1 followed by 400 mg/600 mg every 4 weeks ** 600 mg/900 mg IM every 4 weeks for 2 doses followed by every 8 weeks ** Can be given ±1 week of target date ** If they are going to miss a dose, they should get bridge oral dosing (preference for oral CAB/RPV, but can be anything) * Injectio...") |
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* Studied after viral suppression with oral CAB/RPV, but this is not likely to be necessary |
* Studied after viral suppression with oral CAB/RPV, but this is not likely to be necessary |
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* Dosing |
* Dosing |
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** 600 mg/900 mg IM on week 1 followed by 400 mg/600 mg every 4 weeks |
** '''Monthly:''' 600 mg/900 mg IM on week 1 followed by 400 mg/600 mg every 4 weeks |
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** 600 mg/900 mg IM every 4 weeks for 2 doses followed by every 8 weeks |
** '''Every 2 monthly:''' 600 mg/900 mg IM every 4 weeks for 2 doses followed by every 8 weeks |
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** Can be given ±1 week of target date |
** Can be given ±1 week of target date |
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** If they are going to miss a dose, they should get bridge oral dosing (preference for oral CAB/RPV, but can be anything) |
** If they are going to miss a dose, they should get bridge oral dosing (preference for oral CAB/RPV, but can be anything) |
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* Injections |
* Injections |
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** May need long needle to reach muscle in obese patients |
** May need long needle to reach muscle in obese patients |
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** Often given as <u>r</u>ilpivirine into <u>r</u>ight buttock and cabotegravir into left |
** Often given as [[Rilpivirine|<u>r</u>ilpivirine]] into <u>r</u>ight buttock and cabotegravir into left |
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* Virologic failures |
* Virologic failures |
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** Occur despite perfect adherence |
** Occur despite perfect adherence |
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** Increased if rilpivirine RAMs, low 8-week trough levels, HIV-1 subtype A6 and A3, and with elevated BMI |
** Increased if [[rilpivirine]] RAMs, low 8-week trough levels, HIV-1 subtype A6 and A3, and with elevated BMI |
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* Contraindications: anticoagulation (given risk of IM bleeding), buttock implants, drug-drug interactions, and hepatitis B coinfection |
* Contraindications: anticoagulation (given risk of IM bleeding), buttock implants, drug-drug interactions, and hepatitis B coinfection |
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** Use with caution if risk factors for virologic failure; may warrant closer monitoring |
** Use with caution if risk factors for virologic failure; may warrant closer monitoring |
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Revision as of 18:48, 2 July 2024
- Long-acting injectable medication used to treat HIV
- Studied after viral suppression with oral CAB/RPV, but this is not likely to be necessary
- Dosing
- Monthly: 600 mg/900 mg IM on week 1 followed by 400 mg/600 mg every 4 weeks
- Every 2 monthly: 600 mg/900 mg IM every 4 weeks for 2 doses followed by every 8 weeks
- Can be given ±1 week of target date
- If they are going to miss a dose, they should get bridge oral dosing (preference for oral CAB/RPV, but can be anything)
- Injections
- May need long needle to reach muscle in obese patients
- Often given as rilpivirine into right buttock and cabotegravir into left
- Virologic failures
- Occur despite perfect adherence
- Increased if rilpivirine RAMs, low 8-week trough levels, HIV-1 subtype A6 and A3, and with elevated BMI
- Contraindications: anticoagulation (given risk of IM bleeding), buttock implants, drug-drug interactions, and hepatitis B coinfection
- Use with caution if risk factors for virologic failure; may warrant closer monitoring
