Gardnerella vaginalis: Difference between revisions

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Gardnerella vaginalis
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* [[Bacterial vaginosis]] (a dysbiosis rather than infection) is usually treated with [[metronidazole]], which helps to normalize the overall vaginal microbiome rather than treating the ''Gardnerella''
 
* [[Bacterial vaginosis]] (a dysbiosis rather than infection) is usually treated with [[metronidazole]], which helps to normalize the overall vaginal microbiome rather than treating the ''Gardnerella''
 
* Very little information about antibiotic susceptibility that would be relevant for treating infections
 
* Very little information about antibiotic susceptibility that would be relevant for treating infections
** Based on one Brazilian study, ampicillin/sulbactam, clindamycin, chloramphenicol are likely reliable; ampicillin and metronidazole are not<ref>Knupp de Souza DM, Diniz CG, Filho DSC, Andrade de Oliveira LM, Coelho DM, Talha L de S, Nascimento TC do, Ferreira-Machado AB, Silva VL da (2016) Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women. ''J Infect Dev Ctries'' 10:913–919. doi: [https://doi.org/10.3855/jidc.7161 10.3855/jidc.7161]</ref>
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** Based on one Brazilian study, ampicillin/sulbactam, clindamycin, chloramphenicol are likely reliable; ampicillin and metronidazole are not[[CiteRef::knupp de souza2016an]]
** A case series reports treatment with ceftriaxone, cefuroxime, aminoglycosides, metronidazole, ciprofloxacin<ref>Christine M Akamine, Andrew Chou, Shahriar Tavakoli-Tabasi, Daniel M Musher, ''Gardnerella vaginalis'' Bacteremia in Male Patients: A Case Series and Review of the Literature, ''Open Forum Infectious Diseases'', Volume 9, Issue 10, October 2022, ofac176, doi: [https://doi.org/10.1093/ofid/ofac176 10.1093/ofid/ofac176]</ref>
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** A case series reports treatment with ceftriaxone, cefuroxime, aminoglycosides, metronidazole, ciprofloxacin[[CiteRef::akamine2022ga]]

Latest revision as of 13:10, 19 September 2024


Background

  • Gram-negative or Gram-variable bacillus or coccobacillus
  • Member of vaginal flora

Clinical Manifestations

  • Involved in bacterial vaginosis, a dysbiosis rather than infection
  • Rare cause of other infections, including urinary tract infection

Management

  • Bacterial vaginosis (a dysbiosis rather than infection) is usually treated with metronidazole, which helps to normalize the overall vaginal microbiome rather than treating the Gardnerella
  • Very little information about antibiotic susceptibility that would be relevant for treating infections
    • Based on one Brazilian study, ampicillin/sulbactam, clindamycin, chloramphenicol are likely reliable; ampicillin and metronidazole are not1
    • A case series reports treatment with ceftriaxone, cefuroxime, aminoglycosides, metronidazole, ciprofloxacin2

References

  1. ^  Daniele Maria Knupp de Souza, Claudio Galuppo Diniz, Didier Silveira Castellano Filho, Laura Maria Andrade de Oliveira, Débora Martins Coelho, Luciana de Souza Talha, Thiago César do Nascimento, Alessandra Barbosa Ferreira-Machado, Vânia Lúcia da Silva. Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women. The Journal of Infection in Developing Countries. 2016;10(09):913-919. doi:10.3855/jidc.7161.
  2. ^  Christine M Akamine, Andrew Chou, Shahriar Tavakoli-Tabasi, Daniel M Musher. Gardnerella vaginalis Bacteremia in Male Patients: A Case Series and Review of the Literature. Open Forum Infectious Diseases. 2022;9(10). doi:10.1093/ofid/ofac176.