Loa loa: Difference between revisions
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Loa loa
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**[[Albendazole]] as above to decrease levels below 8000, followed by DEC as above |
**[[Albendazole]] as above to decrease levels below 8000, followed by DEC as above |
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**Apheresis to decrease levels below 8000, followed by DEC as above |
**Apheresis to decrease levels below 8000, followed by DEC as above |
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*[[Levamisole]] 0.25 mg/kg p.o. once is a promising new treatment[[CiteRef::campillo2021sa]] |
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*[[Levamisole]] 0.25 mg/kg p.o. once is a promising new treatment<ref>Jérémy T Campillo, Paul Bikita, Marlhand Hemilembolo, Frédéric Louya, François Missamou, Sébastien D S Pion, Michel Boussinesq, CédricB Chesnais, Safety and Efficacy of Levamisole in Loiasis: A Randomized, Placebo-controlled, Double-blind Clinical Trial, ''Clinical Infectious Diseases'', Volume 75, Issue 1, 1 July 2022, Pages 19–27, https://doi.org/10.1093/cid/ciab906</ref> |
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*Can consider concomitant [[antihistamines]] or [[corticosteroids]] during the first week of treatment to decrease symptoms associated with treatment |
*Can consider concomitant [[antihistamines]] or [[corticosteroids]] during the first week of treatment to decrease symptoms associated with treatment |
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Latest revision as of 17:06, 27 September 2024
Background
Epidemiology
- Transmitted by Chrysops silacea and Chrysops dimidiata flies
- Day biting flies, more common in rainy season and in rain forests
- Attracted by fires and to rubber plantations
- Present in West and Central Africa, primarily in Equatorial Guinea, Gabon, Cameroon, Central African Republic, Congo (Brazzaville), DRC, Nigeria, Chad, Sudan, Angola, Ethiopia
Clinical Manifestations
- Often asymptomatic
- Most common symptom is Calabar swellings, a 10- to 20-cm painful, itchy subcutaneous swelling caused by migration of the adult worms
- The lesions are essentially angioedema in response to the worm
- Worms can also migrate to the conjunctiva, where they are visible
- Infection can be complicated by hematuria and proteinuria
Complications of Treatment
- Treatment with antiparasitics may cause an increase in symptoms such as Calabar swellings or pruritis
- With treatment of high-level parasitemia, can cause fatal encephalopathy
Diagnosis
- Demonatration of microfilaria on Giemsa-stained blood film collected during daytime (10 am to 2 pm)
- Also provides quantification of microfilarial burden
Management
- Not all infections require treatment
- Before treatment
- Must rule out high-level microfilaremia (>2500-8000 microfilariae/mL) before considering medical treatment, due to the risk of encephalopathy
- Rule out Onchocerca volvulus coinfection, as treatment with DEC can lead to blindness or exacerbation of skin disease
- If microfilaremia <8000 MF/mL
- First-line treatment is diethylcarbamazine 8-10 mg/kg/day po divided tid for 21 days
- Kills both the adult worms and microfilaria
- After failing 2 rounds of DEC, albendazole 200 mg bid for 21 days
- First-line treatment is diethylcarbamazine 8-10 mg/kg/day po divided tid for 21 days
- If microfilaremia ≥8000 MF/mL, either:
- Albendazole as above to decrease levels below 8000, followed by DEC as above
- Apheresis to decrease levels below 8000, followed by DEC as above
- Levamisole 0.25 mg/kg p.o. once is a promising new treatment1
- Can consider concomitant antihistamines or corticosteroids during the first week of treatment to decrease symptoms associated with treatment
References
- ^ Jérémy T Campillo, Paul Bikita, Marlhand Hemilembolo, Frédéric Louya, François Missamou, Sébastien D S Pion, Michel Boussinesq, CédricB Chesnais. Safety and Efficacy of Levamisole in Loiasis: A Randomized, Placebo-controlled, Double-blind Clinical Trial. Clinical Infectious Diseases. 2021;75(1):19-27. doi:10.1093/cid/ciab906.
