Rilonacept: Difference between revisions
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Revision as of 01:02, 17 March 2022
- IL-1 inhibitor
- Dimeric fusion protein with the extracellular component of IL-1 receptor fused to the Fc portion of IgG1
- Binds circulating IL-1α and IL-1β
- Indications include cryopyrin-associated periodic syndromes (familial cold autoinflammatory syndrome and Muckle-Wells syndrome)
- Infectious complications include most commonly upper respiratory tract infections, but also pneumococcus, meningitis, NTM, and bronchitis
