Paracoccidioides brasiliensis: Difference between revisions

From IDWiki
Paracoccidioides brasiliensis
m (Aidan moved page Dimorphic to Paracoccidioides brasiliensis without leaving a redirect)
No edit summary
Line 1: Line 1:
 
= Microbiology =
= ''Paracoccidioides brasiliensis'' (paracoccidiomycosis) =
 
 
== Microbiology ==
 
   
 
* Dimorphic fungus with four phylogenetic lineages
 
* Dimorphic fungus with four phylogenetic lineages
Line 7: Line 5:
 
* '''Mariner's wheel''' of budding conidia
 
* '''Mariner's wheel''' of budding conidia
   
== Epidemiology ==
+
= Epidemiology =
   
 
* South and Central America, with Brazil being the largest endemic country
 
* South and Central America, with Brazil being the largest endemic country
 
* Has been isolated from the feces of bats (''Artibeus lituratus'') and from internal organs of the nine-banded armadillo
 
* Has been isolated from the feces of bats (''Artibeus lituratus'') and from internal organs of the nine-banded armadillo
   
== Clinical Presentation ==
+
= Clinical Presentation =
   
 
* Usually self-limited pulmonary infection
 
* Usually self-limited pulmonary infection
Line 23: Line 21:
 
* However, may remain latent following infection, and reactivate later as pulmonary or disseminated disease
 
* However, may remain latent following infection, and reactivate later as pulmonary or disseminated disease
   
== Diagnosis ==
+
= Diagnosis =
   
 
* Serology
 
* Serology
Line 29: Line 27:
 
** Antigen
 
** Antigen
   
== Management ==
+
= Management =
   
 
* Itraconazole 200 to 400 mg/day for 9 to 12 months
 
* Itraconazole 200 to 400 mg/day for 9 to 12 months
 
* If severe, consider amphotericin 1mg/kg/day
 
* If severe, consider amphotericin 1mg/kg/day
 
* ?Septra
 
* ?Septra
  +
 
{{DISPLAYTITLE:''Paracoccidioides brasiliensis''}}
  +
[[Category:Fungi]]

Revision as of 19:20, 14 August 2019

Microbiology

  • Dimorphic fungus with four phylogenetic lineages
  • Disease is caused by P. brasiliensis and P. lutzii (newly discovered)
  • Mariner's wheel of budding conidia

Epidemiology

  • South and Central America, with Brazil being the largest endemic country
  • Has been isolated from the feces of bats (Artibeus lituratus) and from internal organs of the nine-banded armadillo

Clinical Presentation

  • Usually self-limited pulmonary infection
  • Can cause acute/subacute pulmonary infection in children, adolescents, and immunocompromised individuals
    • Fever, weight loss, lymphadenopathy, and hepatosplenomegaly
    • Half have skin and mucosal lesions
  • Can cause chronic disease in adults
    • Pulmonary infiltrates on CXR
    • Adrenal lesions with insufficiency are common
  • However, may remain latent following infection, and reactivate later as pulmonary or disseminated disease

Diagnosis

  • Serology
    • Antibodies
    • Antigen

Management

  • Itraconazole 200 to 400 mg/day for 9 to 12 months
  • If severe, consider amphotericin 1mg/kg/day
  • ?Septra