Acyclovir: Difference between revisions
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*Acyclic guanosine analog that competes with deoxyguanosine triphosphate to inhibit viral DNA polymerase |
*Acyclic guanosine analog that competes with deoxyguanosine triphosphate to inhibit viral DNA polymerase |
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*Resistance mediated by mutation in or decrease of thymidine kinase |
*Resistance mediated by mutation in or decrease of thymidine kinase |
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*Good penetration into CNS and vitreous if administered intravenously, though not orally |
*Good penetration into CNS and vitreous if administered intravenously, though not orally[[CiteRef::huynh2008vi]] |
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*Adverse drug reactions include: |
*Adverse drug reactions include: |
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**[[Adverse drug reaction::Acute kidney injury]] from crystal deposition, so maintain hydration |
**[[Adverse drug reaction::Acute kidney injury]] from crystal deposition, so maintain hydration |
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Revision as of 17:13, 13 February 2021
- Acyclic guanosine analog that competes with deoxyguanosine triphosphate to inhibit viral DNA polymerase
- Resistance mediated by mutation in or decrease of thymidine kinase
- Good penetration into CNS and vitreous if administered intravenously, though not orally1
- Adverse drug reactions include:
- Acute kidney injury from crystal deposition, so maintain hydration
- Phlebitis
- Neurotoxicity, with lethargy, confusion, tremor, myoclonus, agitation, hallucinations, and extrapyramidal symptoms
References
- ^ Tony H. Huynh, Mark W. Johnson, Grant M. Comer, Douglas N. Fish. Vitreous Penetration of Orally Administered Valacyclovir. American Journal of Ophthalmology. 2008;145(4):682-686. doi:10.1016/j.ajo.2007.11.016.
