Foscarnet: Difference between revisions

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*Active against all [[human herpesviruses]]
 
*Active against all [[human herpesviruses]]
   
=== Pharmacokinetics and Pharmacodynamics ===
+
===Pharmacokinetics and Pharmacodynamics===
   
* CSF penetration 66% of serum levels
+
*CSF penetration 66% of serum levels
   
== Dosing ==
+
==Dosing==
   
=== Pediatric Dosing ===
+
===Pediatric Dosing===
   
* Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
+
*Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
* Maintenance: foscarnet 90 to 120 mg/kg IV q24h
+
*Maintenance: foscarnet 90 to 120 mg/kg IV q24h
   
== Safety ==
+
==Safety==
   
  +
*Nephrotoxicity, usually reversible
* Nephrotoxic
 
* Causes electrolyte abnormalities, including [[hypocalcemia]], [[hypophosphatemia]], [[hyperphosphatemia]], [[hypomagnesemia]], and [[hypokalemia]]
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*Electrolyte abnormalities, including [[hypocalcemia]], [[hypophosphatemia]], [[hyperphosphatemia]], [[hypomagnesemia]], and [[hypokalemia]]
  +
*Seizures
  +
*Genital ulcers
  +
*Anemia
  +
*Nausea
   
 
[[Category:Antivirals]]
 
[[Category:Antivirals]]

Revision as of 19:16, 14 September 2020

Background

Spectrum of Activity

Pharmacokinetics and Pharmacodynamics

  • CSF penetration 66% of serum levels

Dosing

Pediatric Dosing

  • Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
  • Maintenance: foscarnet 90 to 120 mg/kg IV q24h

Safety