Foscarnet: Difference between revisions

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*Active against all [[human herpesviruses]]
*Active against all [[human herpesviruses]]


=== Pharmacokinetics and Pharmacodynamics ===
===Pharmacokinetics and Pharmacodynamics===


* CSF penetration 66% of serum levels
*CSF penetration 66% of serum levels


== Dosing ==
==Dosing==


=== Pediatric Dosing ===
===Pediatric Dosing===


* Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
*Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
* Maintenance: foscarnet 90 to 120 mg/kg IV q24h
*Maintenance: foscarnet 90 to 120 mg/kg IV q24h


== Safety ==
==Safety==


*Nephrotoxicity, usually reversible
* Nephrotoxic
* Causes electrolyte abnormalities, including [[hypocalcemia]], [[hypophosphatemia]], [[hyperphosphatemia]], [[hypomagnesemia]], and [[hypokalemia]]
*Electrolyte abnormalities, including [[hypocalcemia]], [[hypophosphatemia]], [[hyperphosphatemia]], [[hypomagnesemia]], and [[hypokalemia]]
*Seizures
*Genital ulcers
*Anemia
*Nausea


[[Category:Antivirals]]
[[Category:Antivirals]]

Revision as of 23:16, 14 September 2020

Background

Spectrum of Activity

Pharmacokinetics and Pharmacodynamics

  • CSF penetration 66% of serum levels

Dosing

Pediatric Dosing

  • Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
  • Maintenance: foscarnet 90 to 120 mg/kg IV q24h

Safety