Foscarnet: Difference between revisions

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== Background ==
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==Background==
   
 
*Inhibits DNA polymerase in [[human herpesviruses]]
 
*Inhibits DNA polymerase in [[human herpesviruses]]
 
*Indications: {{#ask: [[Is treated by::foscarnet]] | default=none}}
 
*Indications: {{#ask: [[Is treated by::foscarnet]] | default=none}}
   
=== Spectrum of Activity ===
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===Spectrum of Activity===
   
* Active against all [[human herpesviruses]]
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*Active against all [[human herpesviruses]]
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  +
=== Pharmacokinetics and Pharmacodynamics ===
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  +
* CSF penetration 66% of serum levels
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  +
== Dosing ==
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  +
=== Pediatric Dosing ===
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  +
* Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
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* Maintenance: foscarnet 90 to 120 mg/kg IV q24h
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== Safety ==
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* Nephrotoxic
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* Causes electrolyte abnormalities, including [[hypocalcemia]], [[hypophosphatemia]], [[hyperphosphatemia]], [[hypomagnesemia]], and [[hypokalemia]]
   
 
[[Category:Antivirals]]
 
[[Category:Antivirals]]

Revision as of 21:20, 11 September 2020

Background

Spectrum of Activity

Pharmacokinetics and Pharmacodynamics

  • CSF penetration 66% of serum levels

Dosing

Pediatric Dosing

  • Induction: foscarnet 60 mg/kg IV q8h or 90 mg/kg IV q12h
  • Maintenance: foscarnet 90 to 120 mg/kg IV q24h

Safety