Rickettsia typhi: Difference between revisions

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Rickettsia typhi
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*[[Causes::Fever]], [[Causes::headache]], [[Causes::nausea]] and [[Causes::vomiting]] are common, as well as [[Causes::myalgias]]
*[[Causes::Fever]], [[Causes::headache]], [[Causes::nausea]] and [[Causes::vomiting]] are common, as well as [[Causes::myalgias]]
*[[Causes::Rash]] develops over the course in about 50%
*[[Causes::Rash]] develops over the course in about 50%
**Usually described as [[Causes::macular rash|Causes::macular]] or [[Causes::maculopapular rash]], sometimes with [[Causes::petechiae]]
**Usually described as [[Causes::macular rash|macular]] or [[Causes::maculopapular rash]], sometimes with [[Causes::petechiae]]
**On trunk, but can involve extremities
**On trunk, but can involve extremities
**Rarely on palms and soles
**Rarely on palms and soles

Revision as of 14:13, 7 September 2020

Background

  • Causes murine typhus, flea-borne typhus, or endemic typhus

Microbiology

  • Flea-borne Gram-negative intracellular bacterium

Life Cycle

  • Flea bites, flea poops, feces get rubbed into the bite wound
  • Flea acquires infection from feeding on a rickettsemic host

Epidemiology

Clinical Manifestations

Diagnosis

  • Based on acute and convalescent serology looking for a 4-fold risk after about 4 weeks
  • Possibly PCR of skin biopsy

Management

  • doxycycline 100 mg PO bid for 7 to 10 days
  • Should be treated empirically, since cannot confirm diagnosis quickly