Marburg virus: Difference between revisions
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==Background== |
==Background== |
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+ | ===Microbiology=== |
*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family |
*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family |
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**Ravn virus |
**Ravn virus |
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+ | ===Epidemiology=== |
| − | * |
+ | *Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases |
| − | * |
+ | *Animal reservoir is [[Reservoir::fruit bat]], with a sylvian cycle that occasionally spills over into human populations |
| − | ** |
+ | **The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa |
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+ | ==Clinical Manifestations== |
| − | * |
+ | *Incubation period [[Usual incubation period::2 to 21 days]] |
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+ | *Starts with high fever, severe headache malaise |
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+ | *Followed by multi-system involvement as early as day 3 |
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+ | **Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week) |
| − | ** |
+ | **Chest pain, dyspnea, cough |
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+ | **Hypotension, edema, maculopapular rash |
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+ | **Headache, confusion |
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+ | *Mortality 23 to 90% |
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+ | == Diagnosis == |
| + | * RT-PCR at the National Microbiology Laboratory |
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| + | ** Inform microbiology lab beforehand and contact Public Health for collection instructions |
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+ | ==Management== |
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| + | ==Prevent== |
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[[Category:Filoviridae]] |
[[Category:Filoviridae]] |
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Revision as of 09:39, 28 August 2020
Background
Microbiology
- Negative-sense single-stranded RNA virus in the Filoviridae family
- Genus contains two species
- Marburg virus
- Ravn virus
Epidemiology
- Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases
- Animal reservoir is fruit bat, with a sylvian cycle that occasionally spills over into human populations
- The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa
Clinical Manifestations
- Incubation period 2 to 21 days
- Starts with high fever, severe headache malaise
- Followed by multi-system involvement as early as day 3
- Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week)
- Chest pain, dyspnea, cough
- Hypotension, edema, maculopapular rash
- Headache, confusion
- Mortality 23 to 90%
Diagnosis
- RT-PCR at the National Microbiology Laboratory
- Inform microbiology lab beforehand and contact Public Health for collection instructions
Management
- Good supportive care decreases mortality substantially
- Experimental therapies include favipiravir and monoclonal antibodies
Prevent
- Vaccination is under investigation
