Linezolid: Difference between revisions
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(Created page with "== Background == * Oxazolidinone antibiotic === Mechanism of Action === * Inhibits the 50S ribosome of Gram-positive bacteria === Spectrum of Activity === * Active agains...") |
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* Cytopenias, including [[Adverse drug reaction::Thrombocytopenia|thrombocytopenia]] (most common), [[Adverse drug reaction::anemia]], and [[Adverse drug reaction::leukopenia]] (least common) |
* Cytopenias, including [[Adverse drug reaction::Thrombocytopenia|thrombocytopenia]] (most common), [[Adverse drug reaction::anemia]], and [[Adverse drug reaction::leukopenia]] (least common) |
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** More common with prolonged use, e.g. after 2 weeks |
** More common with prolonged use, e.g. after 2 weeks |
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[[Category:Antibiotics]] |
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Revision as of 17:47, 22 August 2020
Background
- Oxazolidinone antibiotic
Mechanism of Action
- Inhibits the 50S ribosome of Gram-positive bacteria
Spectrum of Activity
- Active against Gram-positive bacteria
- Not active against Gram-negative bacteria
Dosing
- Linezolid 600 mg PO/IV q12h
Adverse Drug Reactions
- Serotonin syndrome when taken concurrently with certain psychiatric medications
- Ideally hold SSRIs when starting linezolid
- Cytopenias, including thrombocytopenia (most common), anemia, and leukopenia (least common)
- More common with prolonged use, e.g. after 2 weeks
