Burkholderia cepacia complex: Difference between revisions
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Burkholderia cepacia complex
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== Background == |
== Background == |
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* [[Stain::Gram-negative]] [[ |
* [[Stain::Gram-negative]] [[Shape::bacillus]] |
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* Multiple mechanisms of resistance: |
* Multiple mechanisms of resistance: |
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** β-lactamases |
** β-lactamases |
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Revision as of 17:56, 13 October 2020
Background
- Gram-negative bacillus
- Multiple mechanisms of resistance:
- β-lactamases
- RND efflux pumps
- Altered LPS conferring polymixin resistance
- Gyrase mutations conferring fluoroquinolone resistance
Management
- Should be guided by antimicrobial susceptibility testing
- Antibiotic options include:
- TMP-SMX (preferred, if susceptible)
- Ceftazidime and ceftazidime-avibactam
- Meropenem and imipenem
- Minocycline
