Adenovirus: Difference between revisions
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Revision as of 14:34, 7 August 2020
Background
Microbiology
- Non-enveloped double-stranded DNA virus
- Seven species with multiple serotypes
Epidemiology
- Transmitted by droplets or aerosol
Clinical Manifestations
- Common cause of upper respiratory infections in immunocompetent people
- Can also cause acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted)
- In cellular immunodeficiency or neonates, can cause severe disease
- Disseminated disease
- Hemorrhagic cystitis in hematopoietic stem cell transplant
Diagnosis
- Typically by PCR
- May see smudge cells on histology (but not specific)
Management
- Only current effective treatment is cidofovir
